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Upregulation of microparticles in DIC and its impact on inflammatory processes

Saudur Rahman1, Mark Cichon, Debra Hoppensteadt

  • 1Loyola University Medical Center, 2160 South 1st Ave, Maywood, IL, USA. srahma2@lumc.edu

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|March 23, 2011
PubMed

Insights

Microparticles (MPs) are significantly elevated in patients with disseminated intravascular coagulation (DIC), suggesting they play a role in the syndrome's complex hemostatic and inflammatory processes.

Area of Science:

  • Hematology
  • Pathophysiology
  • Cell Biology

Background:

  • Disseminated intravascular coagulation (DIC) involves simultaneous thrombotic and hemorrhagic processes.
  • The roles of inflammation and microparticles (MPs) in DIC pathophysiology are not fully understood.
  • MPs are procoagulant fragments released during cellular disruption and apoptosis.

Purpose of the Study:

  • To quantify microparticle concentration in patients with DIC.
  • To investigate the potential role of MPs in DIC-related hemostatic and inflammatory responses.

Main Methods:

  • Functional MPs were measured in 100 DIC patients and 30 healthy volunteers.
  • Annexin V trapping assay was used to determine the procoagulant activity of MPs.
  • Statistical analysis compared MP levels between DIC patients and controls.

Main Results:

  • Mean MP concentration in DIC patients was 24.6 ± 14.2 nmol/L, significantly higher than controls (8.5 ± 4.3 nmol/L).
  • MP concentration distribution was wider in DIC samples compared to controls.
  • Upregulated MPs were observed in DIC patients.

Conclusions:

  • Microparticles are upregulated in patients with disseminated intravascular coagulation.
  • Elevated MPs may mediate hemostatic activation and inflammatory responses in DIC.
  • Further research is warranted to elucidate the precise mechanisms.

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