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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

Multiple viral coinfections among HIV/AIDS patients in China

N He1, L Chen, H J Lin

  • 1Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China. nhe@shmu.edu.cn

Bioscience Trends
|March 23, 2011
PubMed

Insights

Coinfections with hepatitis C virus (HCV) and herpes simplex virus type 2 (HSV-2) are common in Chinese HIV/AIDS patients and linked to demographics and transmission. Other viral coinfections showed fewer associations.

Area of Science:

  • Infectious Diseases
  • Virology
  • Public Health

Background:

  • Coinfections with viral pathogens are prevalent in individuals with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).
  • Understanding the seroprevalence and correlates of common viral coinfections is crucial for managing HIV/AIDS patients.

Purpose of the Study:

  • To determine the seroprevalence and associated factors of coinfections with hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Barr virus (EBV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2) in Chinese HIV/AIDS patients.
  • To analyze the relationship between these viral coinfections and sociodemographic characteristics, as well as HIV transmission modes.

Main Methods:

  • A cross-sectional survey was conducted among 1,110 HIV/AIDS patients across four provinces in China (Shanxi, Zhejiang, Yunnan, Xinjiang).
  • Serological testing was performed for HBsAg, anti-HCV IgG, anti-EBV IgG, anti-HSV-1 IgG, and anti-HSV-2 IgG.
  • Multiple logistic regression analysis was used to identify correlates of coinfections.

Main Results:

  • High seroprevalence rates were observed for anti-EBV IgG (96.6%), anti-HSV-1 IgG (91.5%), and anti-HCV IgG (59.0%).
  • HCV coinfection was significantly associated with geographic region, age, gender, ethnicity, marital status, and HIV transmission mode.
  • HSV-2 coinfection was associated with geographic region, ethnicity, and HIV transmission mode, while HBV, EBV, and HSV-1 coinfections showed no significant associations with these factors.

Conclusions:

  • Viral coinfection profiles in Chinese HIV/AIDS patients vary significantly based on regional, sociodemographic, and HIV transmission characteristics.
  • HCV and HSV-2 coinfections are particularly influenced by these factors, necessitating tailored healthcare strategies.
  • Differential considerations in healthcare programs are recommended for HIV/AIDS patients with diverse backgrounds and transmission routes to address varying viral coinfection patterns.

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