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Related Experiment Video

Updated: Jun 3, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Microscopic polyangiitis: an unusual neurologic complication.

Hayet Kaaroud¹, Karima Boubaker, Soumaya Beji

¹Department of Neurology, Neurologic Institute, Charles Nicolle Hospital, Tunis, Tunisia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|March 23, 2011

Summary

Microscopic polyangiitis, a small vessel vasculitis, can cause kidney and lung issues. This case highlights a rare neurological complication: epidural inflammation, potentially linked to this autoimmune disease.

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Published on: March 26, 2019

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

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Published on: March 26, 2019

Area of Science:

Rheumatology
Neurology
Nephrology

Background:

Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis affecting small blood vessels.
Typical MPA manifestations include rapidly progressive glomerulonephritis and alveolar hemorrhage.

Observation:

A 30-year-old woman initially presented with rapidly progressive glomerulonephritis.
Seven years after initial diagnosis, she developed partial motor and sensory loss in lower limbs and sphincter dysfunction.

Findings:

This case presents the first documented instance of epidural inflammation associated with microscopic polyangiitis.
The neurological symptoms suggest a potential extension of the vasculitic process.

Implications:

This finding expands the spectrum of neurological complications associated with microscopic polyangiitis.
Further research into autoimmune mechanisms underlying MPA-related neurological involvement is warranted.