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Related Experiment Video

Updated: Jun 3, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
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Published on: May 10, 2017

Peripheral nerve stimulation in chronic cluster headache.

Delphine Magis, Jean Schoenen

    Progress in Neurological Surgery
    |March 23, 2011
    PubMed
    Summary
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    For intractable cluster headaches, great occipital nerve stimulation offers promising results for patients resistant to medication. This neurostimulation technique is recommended before considering deep brain stimulation surgery.

    Area of Science:

    • Neurology
    • Neurosurgery
    • Pain Management

    Background:

    • Cluster headache is a severe primary neurovascular headache condition.
    • A small percentage of chronic cluster headache patients become refractory to all pharmacological treatments.
    • Invasive procedures have been used for refractory cases, but neurostimulation offers new hope.

    Purpose of the Study:

    • To review peripheral nerve stimulation techniques for drug-resistant chronic cluster headache.
    • To focus on the efficacy of great occipital nerve stimulation.
    • To compare neurostimulation with other treatment options.

    Main Methods:

    • Review of existing clinical data on peripheral nerve stimulation for cluster headache.
    • Detailed examination of occipital nerve stimulation techniques and outcomes.

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  • Discussion of other peripheral nerve stimulation approaches like supraorbital and vagus nerve stimulation.

    • Main Results:

    • Great occipital nerve stimulation is the best-evaluated peripheral nerve stimulation technique for drug-resistant chronic cluster headache.
    • This method has provided the most convincing results to date.
    • Current data suggest it should be recommended before deep brain stimulation surgery.

    Conclusions:

    • Occipital nerve stimulation is a viable option for intractable chronic cluster headache.
    • Further placebo-controlled trials are needed to strengthen evidence.
    • Supraorbital and vagus nerve stimulation require more research for cluster headache management.