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04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid autoimmunity and pre-term delivery: brief review and meta-analysis
1Division of Endocrinology, V. Fazzi Hospital, Piazza F. Muratore 73100, Lecce, Italy. robnegro@tiscali.it
Journal of Endocrinological Investigation
|March 23, 2011
Summary
Thyroid autoimmunity is linked to a higher risk of pre-term delivery in pregnant women. This meta-analysis confirms the association, highlighting the need for further research into causal links.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Immunology
Background:
- Thyroid antibodies are present in about 10% of women of childbearing age.
- Thyroid autoimmunity is associated with adverse obstetrical outcomes, including miscarriage and pre-term delivery.
Purpose of the Study:
- To evaluate the association between thyroid autoimmunity and pre-term delivery using available literature data.
Main Methods:
- A systematic literature search was conducted on MEDLINE, EMBASE, and Cochrane Library from 1990 to 2010.
- Keywords related to thyroid antibodies and pre-term delivery were used to identify relevant studies.
Main Results:
- Seven studies, encompassing approximately 23,000 patients, were included in the meta-analysis.
- A significant association was found between thyroid autoimmunity and pre-term delivery, with an odds ratio of 1.67 (95% CI: 1.44-1.94, p<0.001).
Conclusions:
- The meta-analysis confirms a statistical association between thyroid autoimmunity and pre-term delivery.
- Further interventional studies are necessary to clarify a potential cause-effect relationship.
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