Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complement inhibitors and B cell-modifying agents for IgA nephropathy-a Kidney Disease: Improving Global Outcomes (KDIGO) commentary.

Kidney international·2026
Same author

Characterizing the NIH Activity and Chronicity Indices in 2 Independent Lupus Nephritis Cohorts.

Kidney international reports·2026
Same author

Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Executive summary of the KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV).

Kidney international·2025
Same author

KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV).

Kidney international·2025
Same author

Kidney Complement Immunohistochemistry in Thrombotic Microangiopathy Subtypes.

Kidney international reports·2025
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
Same journal

Advancing science and care in CKD-MBD: the layered path to legacy.

Current opinion in nephrology and hypertension·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Complement and glomerular disease: new insights.

Matthew Pickering1, H Terence Cook

  • 1Centre for Complement & Inflammation Research, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

Current Opinion in Nephrology and Hypertension
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Complement dysregulation is linked to glomerular diseases like C3 glomerulopathy and atypical hemolytic uremic syndrome (aHUS). C5 inhibition shows promise for aHUS, but its role in C3 glomerulopathies requires further study.

More Related Videos

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Area of Science:

  • Nephrology
  • Immunology
  • Genetics

Background:

  • Complement dysregulation is closely associated with glomerular pathology.
  • C3 glomerulopathy, including dense deposit disease (DDD) and CFHR5 nephropathy, is characterized by isolated C3 deposition.
  • Atypical hemolytic uremic syndrome (aHUS) involves genetic defects in complement regulation.

Purpose of the Study:

  • To summarize recent advancements in understanding complement dysregulation in glomerular diseases.
  • To review the role of C3 and C5 in the pathogenesis of C3 glomerulopathies and aHUS.
  • To discuss therapeutic strategies targeting the complement system.

Main Methods:

  • Review of recent scientific literature on complement-related glomerular diseases.
  • Analysis of genetic and molecular mechanisms underlying C3 glomerulopathy and aHUS.
  • Evaluation of clinical data and animal models for complement-targeted therapies.

Main Results:

  • C3 glomerulopathy is defined by isolated C3 deposition, with DDD and CFHR5 nephropathy as key examples.
  • Systemic C3 dysregulation underlies familial DDD, while CFHR5 plays a role in kidney complement regulation.
  • Animal models show C5 activation is critical in aHUS-related renal thrombotic microangiopathy and pauci-immune glomerulonephritis.

Conclusions:

  • Eculizumab (anti-C5 antibody) is an effective therapy for aHUS.
  • The therapeutic role of C5 inhibition in C3 glomerulopathies remains an important area for future research.