Related Experiment Videos
Patient-reported outcomes (PRO's) in glaucoma: a systematic review
S Vandenbroeck1, S De Geest, T Zeyen
1Department of Public Health, Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Kapucijnenvoer 35/4, Leuven, Belgium.
Eye (London, England)
|March 23, 2011
Summary
This review found most patient-reported outcome (PRO) instruments for glaucoma lack quality and patient input. The Treatment Satisfaction Survey for Intra Ocular Pressure is a high-quality tool for side effect assessment.
Area of Science:
- Ophthalmology
- Patient-Reported Outcomes
- Health Measurement
Background:
- Patient-reported outcome (PRO) instruments are crucial for assessing glaucoma patient experiences.
- Existing PRO instruments vary in quality and applicability to glaucoma.
Purpose of the Study:
- To systematically review and evaluate PRO instruments for glaucoma.
- To provide guidance on best practices for assessing patient outcomes in glaucoma care.
Main Methods:
- A systematic literature review of papers detailing the development and psychometric properties of glaucoma or vision-specific PRO instruments.
- Assessment of 27 identified PRO instruments against a quality criteria framework.
Main Results:
- Most PRO instruments (18 for glaucoma, 9 for other eye conditions) showed partial adherence to quality standards.
- Functional status tools were of poor quality; Glaucoma Quality of Life Questionnaire and Vision Quality of Life Index are well-developed but used classical validation.
- Rasch-scaled QoL tools (IVI, VCM1) require improved item content; adherence questionnaires need better validity. Treatment Satisfaction Survey for Intra Ocular Pressure is high-quality for topical treatment side effects.
Conclusions:
- Many PRO instruments for glaucoma suffer from poor developmental quality, lacking patient perspectives in item generation and conceptual frameworks.
- Psychometric validation predominantly relies on classical techniques, indicating a need for more robust methodologies.
- Further development and validation are needed for most PRO instruments to accurately capture glaucoma patient experiences and outcomes.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...