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Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

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Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
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Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

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Temporal modulation of spike-timing-dependent plasticity.

Robert C Froemke1, Dominique Debanne, Guo-Qiang Bi

  • 1Molecular Neurobiology Program, Departments of Otolaryngology and Physiology/Neuroscience, The Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine New York, NY, USA.

Frontiers in Synaptic Neuroscience
|March 23, 2011
PubMed
Summary

Spike-timing-dependent plasticity (STDP) involves complex interactions beyond simple spike pairs. This review explores how factors like spike rate and precise timing influence synaptic changes in the brain.

Keywords:
LTDLTPSTDPcortexhippocampusmodelspikessynaptic plasticity

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Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

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Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Computational Neuroscience

Background:

  • Spike-timing-dependent plasticity (STDP) is a fundamental mechanism for synaptic modification.
  • The basic STDP model uses single spike pairs to predict changes in synaptic strength.
  • Real neuronal communication involves complex spike patterns, influencing synaptic integration.

Purpose of the Study:

  • To review experimental evidence for nonlinear temporal interactions in STDP.
  • To investigate factors affecting synaptic modification beyond simple spike pairs.
  • To discuss the development of predictive models for STDP with complex spike trains.

Main Methods:

  • Review of experimental findings on STDP in cortical and hippocampal synapses.
  • Analysis of factors influencing synaptic plasticity, including spike rate and timing.
  • Discussion of computational modeling approaches for complex spike trains.

Main Results:

  • STDP exhibits nonlinear temporal interactions influenced by multiple factors.
  • Postsynaptic excitability and short-term depression significantly impact synaptic modification.
  • Complex spike trains can induce predictable long-term synaptic changes.

Conclusions:

  • Synaptic plasticity is modulated by intricate spike timing and network activity.
  • Understanding these nonlinearities is crucial for accurate models of learning and memory.
  • Quantitative models are advancing our ability to predict synaptic changes from naturalistic spike trains.