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Related Concept Videos

Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
Synaptic Signaling01:12

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.

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Related Experiment Video

Updated: Jun 3, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
07:30

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons

Published on: September 4, 2017

Sharing vesicles between central presynaptic terminals: implications for synaptic function.

Kevin Staras1, Tiago Branco

  • 1School of Life Sciences, University of Sussex Brighton, UK.

Frontiers in Synaptic Neuroscience
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Mobile vesicles in hippocampal neurons form a "superpool," sharing across synapses. This challenges traditional models and suggests a new mechanism for synaptic plasticity and communication.

Keywords:
imagingneuronpresynaptic terminalsynaptic transmissionsynaptic vesicle

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Related Experiment Videos

Last Updated: Jun 3, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
07:30

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Examination of Synaptic Vesicle Recycling Using FM Dyes During Evoked, Spontaneous, and Miniature Synaptic Activities
08:10

Examination of Synaptic Vesicle Recycling Using FM Dyes During Evoked, Spontaneous, and Miniature Synaptic Activities

Published on: March 31, 2014

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • Presynaptic terminals contain distinct vesicle pools crucial for synaptic strength.
  • Classical models assume vesicle pools are synapse-specific.
  • Emerging evidence suggests lateral vesicle mobility along axons.

Purpose of the Study:

  • To outline the characteristics of a synapse-spanning vesicle pool, termed "superpool".
  • To discuss the structural organization and relationship of this superpool with conventional vesicle pools.
  • To examine the functional implications of lateral vesicle sharing.

Main Methods:

  • Review of existing literature on vesicle dynamics and extrasynaptic mobility.
  • Comparative analysis of mobile vesicle pools and non-vesicular synaptic elements.
  • Theoretical framework for understanding synapse-spanning vesicle pools.

Main Results:

  • Mobile vesicles can be shared across adjacent presynaptic terminals, forming a functional "superpool".
  • This superpool challenges the concept of synapse-specific vesicle pools.
  • Lateral vesicle sharing impacts individual terminal release capabilities and synaptic plasticity.

Conclusions:

  • Synapse-spanning vesicle pools represent a novel class of synaptic organization.
  • Lateral vesicle mobility influences synaptic function and offers a substrate for plasticity.
  • The operational independence of adjacent release sites is questioned by mobile vesicle dynamics.