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Regional changes in gene expression after limbic kindling.

M E Corcoran¹, R A Kroes, J S Burgdorf

¹Neural Systems and Plasticity Research Group and Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK S7N 3R2, Canada. michael.corcoran@usask.ca

Cellular and Molecular Neurobiology

|March 23, 2011

Summary

This summary is machine-generated.

Kindling, a process of repeated electrical stimulation, causes permanent changes in gene expression in the amygdala and hippocampus. These molecular alterations are site-specific, influencing brain function and behavior long-term.

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Repeated electrical stimulation leads to kindling, characterized by increased seizure susceptibility and permanent changes in gene expression.
Kindling-induced behavioral changes, like altered spatial cognition and anxiety, suggest site-specific gene expression modifications in brain regions such as the amygdala and hippocampus.

Purpose of the Study:

To investigate chronic gene expression changes in the amygdala and hippocampus following kindling using focused microarray analysis.
To identify specific neurochemical pathways altered by kindling in these distinct brain regions.

Main Methods:

Male Long-Evans rats underwent daily electrical stimulation of the amygdala or hippocampus until five generalized seizures were kindled.
Control rats carried electrodes but received no stimulation.
Amygdala and hippocampus tissues were collected 14 days post-seizure for transcriptome profiling.

Main Results:

Kindling altered the expression of 39 genes in the amygdala and 106 genes in the hippocampus compared to controls.
Amygdala kindling revealed enrichment in genes related to cytoskeletal reorganization, cation transport, synaptic transmission, and neurogenesis.
Hippocampal kindling showed enrichment in cytoskeletal reorganization, cation transport, transcription factor activity, and GTPase-mediated signal transduction.

Conclusions:

Kindling induces chronic, site-specific alterations in gene expression within the amygdala and hippocampus.
These molecular changes involve distinct pathways, including cytoskeletal dynamics, ion transport, and signal transduction, potentially explaining region-specific behavioral deficits observed interictally.