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Heart Valves

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

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Related Experiment Video

Updated: Jun 3, 2026

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

[Tissue engineering of heart valves].

P Akhyari¹, P Minol, A Assmann

¹Klinik für Kardiovaskuläre Chirurgie, Universitätsklinik Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany. Payam.Akhyari@med.uni-duesseldorf.de

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen

|March 23, 2011

Summary

Current heart valve prostheses have limitations. Tissue-engineered, decellularized donor heart valves offer a promising regenerative alternative for cardiac valvular disease, gaining clinical attention.

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Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

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Last Updated: Jun 3, 2026

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

Published on: July 23, 2014

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

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Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

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Area of Science:

Cardiovascular Medicine
Biomaterials Science
Regenerative Medicine

Context:

Cardiac valvular disease treatment has advanced with prostheses.
Existing prostheses face challenges like limited durability and need for anticoagulation.
Tissue engineering offers novel solutions for regenerative heart valve replacements.

Purpose:

To explore advancements in heart valve prostheses.
To highlight the potential of tissue-engineered regenerative prostheses.
To discuss the clinical relevance of decellularized donor heart valves.

Summary:

Tissue engineering strategies are being developed to create vital and regenerative heart valve prostheses.
Approaches include using biological or synthetic scaffolds enhanced with cellular/extracellular components.
Decellularized donor heart valves represent a leading regenerative option with increasing clinical adoption.

Impact:

Decellularized heart valves show promise for improved long-term durability and reduced need for anticoagulation.
This regenerative approach could overcome limitations of current prosthetic devices.
Growing clinical attention signifies the potential of tissue-engineered valves in cardiovascular therapy.