Related Experiment Video
Updated: Jun 3, 2026
Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
Published on: November 17, 2023
Current perspectives on Gleason grading of prostate cancer
Kenneth A Iczkowski1, M Scott Lucia
1Department of Pathology, University of Colorado Denver School of Medicine, RC-1 North, 12800 East 19th Avenue, Campus Mail Stop 8104, Aurora, CO 80045, USA. betsyandkenneth@yahoo.com.
Abstract:
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized.
