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Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Acute intrahepatic cholestasis accompanied with Chlamydophila pneumoniae infection
Megumi Toyoda-Akui1, Hiroaki Yokomori, Fumihiko Kaneko
1Department of Internal Medicine, Kitasato University, Kitasato Institute Medical Center Hospital, 6-100 Arai, Kitamoto-shi, Saitama, 364-8501, Japan. m.toyoda@insti.kitasato-u.ac.jp
Abstract:
We report a case of Chlamydophila (C.) pneumoniae infection presenting with fever and rapid intrahepatic cholestasis. A 63-year-old man had a week-long history of intermittent high fever and rapidly progressive jaundice with atypical erythema. The results of liver function tests were recorded. The results of all serological tests were negative; the IgM, IgG, and IgA titers for C. pneumoniae had increased, which indicates a C. pneumoniae infection. The patient's fever and liver dysfunction improved upon administration of minocycline. Light microscopic findings showed the presence of enlarged liver cells with clear cytoplasm, a few mitotic figures, multinucleated cells, and bile cholestasis. The electron microscopic appearance of liver biopsy showed that bile canaliculi exhibited intrahepatic forms of cholestasis. From the results of light and electron microscopy, we inferred atypical intrahepatic cholestasis, probably resulting from the C. pneumoniae infection.
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