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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Behavior of aqueous nanocrystalline hydroxyapatite in oral bone regeneration
Davide Zaffe1, Giorgio Traversa, Marco Mozzati
1Department of Biomedical Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, Modena, Italy. davide.zaffe@unimore.it
Purpose:
A skeletal segment consisting exclusively of bone is the target outcome of bone regeneration. Granular hydroxyapatites form a hydroxyapatite-bone composite, unsuitable for effectively supporting implants, which may persist for many years. This work aimed to investigate the reasons for the bone replacement of Ostim®, a recently commercialized aqueous nanocrystalline hydroxyapatite.
Methods:
Histology, SEM and X-ray microanalysis were employed to analyze 6- to 9-month biopsies of post-extractive sites or sinus floor lifts of the maxilla in 15 subjects.
Results:
The results highlight a great bone formation, Ostim® resorption with time by osteoclasts but also interstitial fluid propagation of Ostim® masses by percolation. A possible osteocyte protoplasmic involvement was also at work in concert to reach the target.
Conclusions:
The use of Ostim® as bone regenerating material leads to the formation of a highly suitable implant support consisting exclusively of bone in less than 12 months, i.e. in a remarkably short time.
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