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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jun 3, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

MicroRNAs in inflammatory bowel disease.

Joel R Pekow1, John H Kwon

  • 1Section of Gastroenterology, Department of Medicine, University of Chicago, Illinois 60637, USA.

Inflammatory Bowel Diseases
|March 23, 2011
PubMed
Summary

MicroRNAs (miRNAs) regulate gene expression and are vital for immune responses. Altered miRNA profiles are implicated in inflammatory bowel disease (IBD) pathogenesis, offering potential for new diagnostics and treatments.

Area of Science:

  • Molecular Biology
  • Immunology
  • Gastroenterology

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene and protein expression.
  • miRNAs play a crucial role in immune system function and are dysregulated in immune-mediated disorders.
  • Aberrant miRNA expression is increasingly recognized in the pathogenesis of various diseases.

Purpose of the Study:

  • To review the role of miRNA expression in inflammation, autoimmune disorders, and cancer.
  • To explore the significance of miRNA profiles in inflammatory bowel disease (IBD).
  • To discuss the potential of miRNAs in understanding IBD pathogenesis and developing clinical strategies.

Main Methods:

  • Literature review focusing on miRNA expression and function.

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

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  • Analysis of studies investigating miRNA profiles in inflammatory conditions.
  • Synthesis of current knowledge on miRNA involvement in IBD.

    • Main Results:

    • miRNAs are critical regulators of immune responses.
    • Altered miRNA expression is a hallmark of immune-mediated diseases, including IBD.
    • miRNA dysregulation contributes to the pathogenesis of inflammation and associated cancers.

    Conclusions:

    • miRNA expression profiling in IBD provides insights into disease mechanisms.
    • Understanding miRNA function in IBD can lead to novel diagnostic and therapeutic approaches.
    • miRNAs represent a promising area for advancing IBD management.