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Related Experiment Video

Updated: Jun 3, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Axonal damage in multiple sclerosis.

Jeffery D Haines¹, Matilde Inglese, Patrizia Casaccia

¹Departments of Neuroscience Neurology and Genetics and Genomics, Mount Sinai School of Medicine, New York, NY, USA.

The Mount Sinai Journal of Medicine, New York

|March 23, 2011

Summary

This summary is machine-generated.

Multiple sclerosis involves immune-mediated myelin destruction and neurodegeneration, causing disability. Understanding diverse axonal damage mechanisms is crucial for developing effective multiple sclerosis treatments.

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Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

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Published on: February 23, 2024

Area of Science:

Neuroimmunology
Neurodegeneration
Central Nervous System Disorders

Background:

Multiple sclerosis (MS) is characterized by immune-mediated myelin destruction in the central nervous system (CNS).
Neurodegeneration, a key driver of clinical disability in MS, is only partially addressed by current immunomodulatory therapies.

Purpose of the Study:

To review distinct mechanisms of axonal damage in multiple sclerosis.
To explore pathways of axonal degeneration that are either consequent to or independent of demyelination.

Main Methods:

Literature review of pathogenesis mechanisms in multiple sclerosis.
Analysis of studies investigating axonal damage in relation to demyelination.

Main Results:

Axonal damage in MS arises from complex, heterogeneous mechanisms.
These mechanisms can be linked to long-term demyelination or occur independently.

Conclusions:

The multifaceted nature of axonal degeneration in MS necessitates consideration of diverse pathogenetic pathways.
Targeted therapeutic interventions for MS should account for the heterogeneity of axonal damage mechanisms.