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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Multiple sclerosis: where will we be in 2020?

Aaron E Miller1

  • 1Mount Sinai School of Medicine, New York, NY, USA. aaron.miller@mssm.edu

The Mount Sinai Journal of Medicine, New York
|March 23, 2011
PubMed
Summary
This summary is machine-generated.

Research in multiple sclerosis (MS) therapeutics has rapidly advanced, focusing on immunology and genetics. Future understanding and treatment of MS will likely see significant progress by the end of this decade.

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Area of Science:

  • Neuroimmunology
  • Genetics of Multiple Sclerosis

Background:

  • Multiple Sclerosis (MS) research has surged in the last decade.
  • Investigative efforts into MS therapeutics have accelerated.
  • Complex immunological perturbations contributing to MS are being dissected.

Purpose of the Study:

  • To address current investigative issues in multiple sclerosis.
  • To offer predictions on the future of MS understanding and treatment.
  • To project the state of MS research by the end of the 21st century's second decade.

Main Methods:

  • Review of recent immunological research in MS.
  • Analysis of advances in understanding MS genetics.
  • Synthesis of current investigative findings.

Main Results:

  • Significant progress in dissecting MS-related immunological perturbations.
  • Major advances in understanding the genetic basis of MS.
  • Identification of key areas for future MS research.

Conclusions:

  • The field of multiple sclerosis research is dynamic and rapidly evolving.
  • Understanding of MS pathogenesis and genetics has significantly improved.
  • Future advancements in MS treatment are anticipated by 2020.