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Related Experiment Videos

[Chorionic villi sampling: experience of the initial 500 samples].

C Donner1, P Simon, F Gosselin

  • 1Laboratoire de cytogénétique, Hôpital Universitaire Brugmann.

Revue Medicale De Bruxelles
|June 1, 1990
PubMed
Summary

First trimester antenatal diagnosis using chorionic villus sampling (CVS) is effective. This study shows high diagnostic rates and low maternal complications for early pregnancy assessment.

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Area of Science:

  • Obstetrics and Gynecology
  • Prenatal Diagnostics
  • Medical Genetics

Context:

  • Since 1984, first-trimester antenatal diagnosis has been performed.
  • 498 pregnancies underwent transcervical chorionic villus sampling (CVS).
  • Maternal age was a key indication for genetic screening.

Purpose:

  • To report experience with first-trimester antenatal diagnosis.
  • To evaluate the efficacy and safety of chorionic villus sampling (CVS).
  • To determine diagnostic rates and complication profiles.

Summary:

  • The study found a 6% rate of abnormal pregnancies.
  • Chromosomal abnormalities (trisomy) were detected in 2% of cases with advanced maternal age.
  • A diagnosis was achieved in 92.8% after one CVS, and 99% overall through subsequent procedures (CVS, amniocentesis, cordocentesis).

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  • The fetal loss rate was 3.4% (until 28 weeks), with procedure-related and background loss at 2.4% (12 cases).
  • No maternal complications were observed.

    • Impact:

    • Provides long-term data on the safety and effectiveness of first-trimester CVS.
    • Highlights the diagnostic yield of CVS for identifying fetal abnormalities.
    • Demonstrates the high success rate of achieving antenatal diagnosis for informed reproductive decision-making.
    • Supports the role of CVS as a valuable tool in prenatal care.