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A two-component small molecule system for activity-based detection and signal amplification: application to the
Matthew S Baker1, Scott T Phillips
1Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Abstract:
A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.
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