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The effects of cinnarizine on menopausal symptoms in women
P Y Cezarino1, V R Bagnoli, A M Fonseca
1University of São Paulo, Sao Paulo, Brzil.
Objective:
To evaluate the effectiveness and safety of cinnarizine in the treatment of menopausal symptoms.
Design:
A total of 100 climacteric and symptomatic women participated in a double-blind, placebo-controlled study. They were divided into two groups of the same size: Gcin, intake of 25 mg of cinnarizine every 12 h for 6 months (n=50); and Gpla, placebo intake every 12 hours for 6 months (n=50). Menopausal symptoms were evaluated according to the Kupperman menopausal index on the first visit and at 6 months of treatment. A total of 62 women completed the study: 27 from the Gcin group and 35 from the Gpla group.
Results:
Based on the Kupperman menopausal index, there were no statistically significant differences between the two groups before and after the treatment.
Conclusion:
Our data suggest cinnarizine is not effective on menopausal symptoms because it had no more efficacy than placebo.
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