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Mesenchymal hamartoma of the liver with inversion of chromosome 19
Shashirekha Shetty1, Alfredo Pinto, Birgitte Roland
1Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. shettys@ccf.org
Abstract:
ABSTRACT A mesenchymal hamartoma of the liver (MHL) from a 20-month-old girl was studied cytogenetically. The karyotype was 46,XX,inv(19)(p13q13.4)[38], and fluorescence in situ hybridization using bacterial artificial chromosome probes refined the breakpoints to 19p13.11 and the subtelomeric region of 19q. This is the first report of inversion (19) in MHL, and the q-arm breakpoint is different from that reported previously in other rearrangements.
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