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Factors associated with silent cerebral microbleeds in hemodialysis patients

T Naganuma1, Y Takemoto, T Yamasaki

  • 1Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan. spxd48k9@aria.ocn.ne.jp

Clinical Nephrology
|March 24, 2011
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) are common in hemodialysis patients, with older age and high blood pressure being key risk factors. These findings highlight CMBs as a marker of small vessel disease in this population.

Area of Science:

  • Neurology
  • Nephrology
  • Radiology

Background:

  • Cerebral microbleeds (CMBs) detected by gradient-echo T2*-weighted MRI may indicate intracerebral hemorrhage risk and cerebral small-vessel disease.
  • The prevalence and clinical factors of CMBs in hemodialysis (HD) patients require investigation.

Purpose of the Study:

  • To investigate the prevalence of CMBs in hemodialysis patients.
  • To identify clinical factors associated with CMBs in HD patients.
  • To explore the relationship between CMBs and other cerebral small-vessel diseases.

Main Methods:

  • Cranial MRI with T2*-weighted imaging was performed on 179 HD patients and 58 healthy controls.
  • Prevalence of CMBs and associated clinical factors were analyzed.
  • Correlation between CMBs and other markers of small vessel disease was assessed.

Main Results:

  • CMBs were significantly more prevalent in HD patients (25.1%) compared to healthy controls (0%).
  • Independent factors associated with CMBs included older age, systolic blood pressure, diastolic blood pressure, and pulse pressure.
  • CMBs showed significant correlation with lacunar infarcts and white matter hyperintensities.

Conclusions:

  • Hemodialysis patients exhibit a high prevalence of cerebral microbleeds.
  • Older age and elevated blood pressure are significant risk factors for CMBs in HD patients.
  • CMBs are closely linked to other manifestations of cerebral small-vessel disease.

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