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Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Author Spotlight: Advanced Treatment of Seminal Duct Blockage Employing Endoscopy-Mediated Semen Channel Refluviation

Published on: December 8, 2023

Primary seminal vesicle carcinoma.

Peter Stenzel¹, George Wettach, Xavier Leroy

¹Department of Pathology, Oregon Health and Science University, Portland, OR 97239-3098, USA. stenzelp@ohsu.edu

International Journal of Surgical Pathology

|March 24, 2011

Summary

Diagnosis of primary seminal vesicle carcinoma can be challenging. This case highlights how immunohistochemistry can aid in identifying seminal vesicle origin in disseminated cancer, even with stringent criteria.

Area of Science:

Uropathology
Surgical Pathology
Oncology

Background:

Primary seminal vesicle carcinoma is exceptionally rare, with historically stringent diagnostic criteria.
Immunohistochemistry offers potential to refine diagnosis of male pelvic mass lesions.

Observation:

A case of disseminated carcinoma with an occult primary site originating in the seminal vesicle is presented.
Autopsy revealed a large tumor enveloping the prostate and seminal vesicles, with smaller metastatic tumors elsewhere.
Histological examination showed poorly formed glands and malignant cells involving the seminal vesicle.

Findings:

The tumor exhibited an immunohistochemical profile consistent with seminal vesicle carcinoma.
Key markers included strong CA-125 immunoreactivity and absence of cytokeratin-20 and prostate-specific markers.

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This profile supports a seminal vesicle origin despite the disseminated nature of the cancer.

Implications:

Relaxed diagnostic criteria, aided by immunohistochemistry, may improve the identification of rare seminal vesicle carcinomas.
This case expands understanding of seminal vesicle carcinoma presentation and metastatic potential.
Accurate diagnosis is crucial for appropriate patient management and further research into this rare malignancy.