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The possible risk of cancer in claudicants

Bettina-Maria Taute1, Stephan Thommes, Ralf Taute

  • 1Department of Internal Medicine III/Angiology, University Clinics of the Martin Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, Halle (Saale), Germany. bettina.taute@medizin.uni-halle.de

Angiology
|March 24, 2011
PubMed

Insights

In patients with intermittent claudication, vascular and cancer-related deaths became equally significant over 10 years. Improved vascular care may shift mortality towards cancer, highlighting the need for comprehensive prevention strategies.

Area of Science:

  • Vascular Medicine
  • Oncology
  • Public Health

Background:

  • Peripheral artery disease, specifically intermittent claudication, necessitates long-term monitoring.
  • Secondary prevention strategies aim to reduce vascular events in these patients.
  • Understanding non-vascular comorbidities is crucial for comprehensive patient outcomes.

Purpose of the Study:

  • To track vascular and non-vascular events in patients with intermittent claudication over a decade.
  • To analyze causes of mortality in this cohort.
  • To assess the impact of secondary prevention on patient outcomes.

Main Methods:

  • Prospective 10-year follow-up of 109 patients with mild intermittent claudication.
  • Recording of all vascular and non-vascular events.
  • Analysis of mortality causes, including vascular events, cancer, and other factors.

Main Results:

  • 534 events were recorded in 109 patients.
  • Overall mortality was 25.7%, with 39% vascular and 36% cancer-related deaths.
  • Smoking-related cancers occurred early (within 5 years), while severe vascular events appeared later.
  • Mortality was equally attributed to vascular and cancer comorbidities.

Conclusions:

  • Improvements in vascular care have shifted mortality patterns.
  • Cancer incidence and mortality are becoming increasingly significant in claudicant populations.
  • Integrated secondary prevention addressing both vascular and oncological risks is essential.

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