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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 3, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

PTH and stem cells.

M Ohishi1, E Schipani

  • 1Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Journal of Endocrinological Investigation
|March 24, 2011
PubMed
Summary
This summary is machine-generated.

Parathyroid hormone (PTH) influences bone marrow stem cells. PTH treatment affects hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), potentially impacting marrow fibrosis development.

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Area of Science:

  • Bone biology and stem cell research.

Background:

  • Adult bone marrow contains hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), crucial for bone marrow stroma.
  • Marrow fibrosis, an expansion of bone marrow stroma, is linked to disorders like hyperparathyroidism and fibrous dysplasia.
  • Parathyroid hormone (PTH) is an FDA-approved osteoporosis treatment.

Purpose of the Study:

  • To review current knowledge on PTH's relationship with stem cells.
  • To discuss the role of different cell types in marrow fibrosis.
  • To explore PTH signaling's involvement in marrow fibrosis pathology.

Main Methods:

  • Literature review of studies on PTH, bone marrow stem cells, and marrow fibrosis.
  • Analysis of existing data on PTH effects on HSC and MSC populations.
  • Synthesis of information regarding cellular contributions to marrow fibrosis.

Main Results:

  • PTH treatment may alter HSC numbers and mobilization.
  • Mesenchymal stem cells/progenitors express PTH receptors and increase with PTH treatment.
  • PTH signaling is implicated in the development of marrow fibrosis.

Conclusions:

  • PTH significantly interacts with bone marrow stem cell populations.
  • Understanding PTH's role in stem cell dynamics is crucial for bone marrow fibrosis research.
  • Further investigation into PTH signaling pathways may reveal therapeutic targets for marrow fibrosis.