Treatment for atrophic macular degeneration

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Updated: Jun 3, 2026

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
10:24

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

Annal D Meleth1, Wai T Wong, Emily Y Chew

  • 1National Eye Institute/National Institutes of Health, Bethesda, Maryland, USA.

Current Opinion in Ophthalmology
|March 24, 2011
PubMed
Abstract

Insights

Numerous investigational treatments for geographic atrophy (GA) linked to age-related macular degeneration are in development. However, no effective therapies have been proven to date for this condition.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Clinical Trials

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Geographic atrophy (GA) is an advanced form of AMD characterized by progressive retinal cell death.
  • Current treatment options for GA are limited.

Purpose of the Study:

  • To provide a comprehensive summary of ongoing and recently completed clinical trials for geographic atrophy (GA).
  • To review the landscape of investigational agents targeting GA associated with age-related macular degeneration (AMD).

Main Methods:

  • Systematic review of clinical trial databases.
  • Analysis of recently completed and ongoing studies.
  • Inclusion of trials in pre-clinical and early-phase clinical testing.

Main Results:

  • A substantial number of investigational agents are currently under development for GA treatment.
  • These agents are in various stages of clinical testing, from pre-clinical to early-phase trials.
  • The development pipeline includes therapies targeting diverse aspects of GA pathogenesis.

Conclusions:

  • Multiple therapeutic strategies are being explored for geographic atrophy.
  • Despite extensive research and development, no treatments have yet demonstrated efficacy.
  • Further research is needed to identify effective therapies for GA.

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