Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network analysis of NRG1 variants of uncertain significance (VUSes) in advanced non-small-cell lung cancer and their prognostic role in EGFR-mutant patients treated with first-line osimertinib.

ESMO open·2025
Same author

Ultrasound-guided needle aspiration biopsy of isolated anterior mediastinal masses.

Pulmonology·2022
Same author

Impact of the COVID-19 pandemic on HPV vaccination coverage in the general population and in PLWHs.

European review for medical and pharmacological sciences·2022
Same author

Clinical course of IPF in Italian patients during 12 months of observation: results from the FIBRONET observational study.

Respiratory research·2021
Same author

Structured reporting of chest CT in COVID-19 pneumonia: a consensus proposal.

Insights into imaging·2020
Same author

Diagnosis and treatment of early and locally advanced non-small-cell lung cancer: The 2019 AIOM (Italian Association of Medical Oncology) clinical practice guidelines.

Critical reviews in oncology/hematology·2020
Same journal

Breast carcinoma metastasizing to an adrenocortical adenoma: a case of tumour-to-tumour metastasis.

Pathologica·2026
Same journal

Metastatic melanoma with heterologous bone after neoadjuvant immunotherapy: diagnostic insights.

Pathologica·2026
Same journal

Lymphangitic breast cancer in explanted lungs with interstitial lung disease: an unexpected finding.

Pathologica·2026
Same journal

Histological insights into sudden, unexpected death due to tuberculosis: two autopsy case reports and review of the literature.

Pathologica·2026
Same journal

Teaching with human remains: curatorship, technological innovation and ethical engagement at the Morgagni Museum of Human Anatomy.

Pathologica·2026
Same journal

Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study.

Pathologica·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

Granulomatous lung disease.

A Cancellieri1, G Dalpiaz, R Trisolini

  • 1Department of Pathology, Maggiore Hospital, Bologna, Italy. alessandra.cancellieri@ausl.bologna.it

Pathologica
|March 25, 2011
PubMed
Summary
This summary is machine-generated.

This study highlights the importance of combining imaging and pathology to diagnose granulomatous lung diseases. Understanding granuloma distribution and features aids in identifying causes like infections or sarcoidosis.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Pathology
  • Radiology
  • Pulmonology

Background:

  • Granulomas present diagnostic challenges in various conditions.
  • Interstitial lung diseases (ILDs) frequently involve granulomas, stemming from infections, immunological responses, or idiopathic causes.
  • Key morphological features include necrosis, granuloma cohesion, fibrosis, and inflammatory infiltrate.

Purpose of the Study:

  • To propose a combined radiological-histopathological approach for diagnosing granulomatous ILDs.
  • To detail the morphological features and anatomic distribution of granulomas within the secondary lobule.
  • To review clinical features and diagnostic procedures for respiratory samples.

Main Methods:

  • Combined radiological and histopathological analysis.
  • Evaluation of granuloma morphology (necrosis, cohesiveness, fibrosis, inflammation).
  • Assessment of granuloma distribution patterns (lymphatic, random, airway-associated).

Main Results:

  • Granuloma distribution patterns (lymphatic, random, airway) are crucial for diagnosis.
  • Specific patterns correlate with conditions like sarcoidosis, mycobacterial infections, and hypersensitivity pneumonitis.
  • Morphological assessment aids in differentiating causes of granulomatous lung disease.

Conclusions:

  • A combined imaging-pathology approach enhances the diagnosis of granulomatous ILDs.
  • Understanding granuloma location and morphology is key to identifying underlying etiologies.
  • Comprehensive clinical and procedural review supports accurate diagnosis and management.