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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Targeted therapy in colorectal cancer: current status and future challenges

A K Koutras1, I Starakis, U Kyriakopoulou

  • 1Division of Oncology, Department of Medicine, University Hospital, Patras Medical School, Rion 26504, Greece. angkoutr@otenet.gr

Current Medicinal Chemistry
|March 25, 2011
PubMed
Summary

Targeted therapies, including anti-EGFR and anti-VEGF agents, have advanced metastatic colorectal cancer (mCRC) treatment. This review updates clinical studies, resistance mechanisms, biomarkers, and future strategies for these important mCRC therapies.

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