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Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Global Regulatory Systems

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Interactions Between Signaling Pathways

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Related Experiment Video

Updated: Jun 3, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Tribbles: 'puzzling' regulators of cell signalling.

Endre Kiss-Toth1

  • 1Department of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. e.kiss-toth@sheffield.ac.uk

Biochemical Society Transactions
|March 25, 2011
PubMed
Summary

Tribbles pseudokinases regulate cell signaling pathways. Dysregulation of these pathways contributes to human diseases, highlighting their importance in health and disease.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Cellular signal transduction is crucial for life, enabling organisms to respond to environmental changes.
  • Intracellular protein networks form the machinery for signal transduction, essential for maintaining homeostasis.
  • Dysregulation of signaling pathways can lead to disease and organism death.

Purpose of the Study:

  • To summarize recent developments in understanding the role of tribbles pseudokinases in signal transduction.
  • To explore the involvement of tribbles family members in human diseases.
  • To provide insights into the mechanisms by which tribbles proteins contribute to disease pathology.

Main Methods:

  • Review of recent scientific literature on tribbles pseudokinases.

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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

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Last Updated: Jun 3, 2026

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  • Analysis of protein interaction networks involving tribbles, kinases, ubiquitin ligases, and transcription factors.
  • Examination of evidence linking tribbles family members to various human diseases.

    • Main Results:

    • Tribbles pseudokinases act as key regulators of signal transduction pathways.
    • These pseudokinases interact with critical components of cellular signaling machinery, including kinases and transcription factors.
    • Members of the tribbles family are implicated in the pathogenesis of several human diseases.

    Conclusions:

    • Tribbles pseudokinases are significant controllers of intracellular signaling.
    • Their dysregulation is linked to human disease development.
    • Further research is needed to fully elucidate the mechanistic roles of tribbles in disease.