Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease course and symptoms in smoking versus non-smoking patients with Celiac disease.

Acta gastro-enterologica Belgica·2026
Same author

Oral delivery of fluticasone powder improves esophageal eosinophilic inflammation and symptoms in adults with eosinophilic esophagitis.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2018
Same author

Colectomy Rates in Ulcerative Colitis are Low and Decreasing: 10-year Follow-up Data From the Swiss IBD Cohort Study.

Journal of Crohn's & colitis·2018
Same author

Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis.

Allergy·2017
Same author

Eosinophilic esophagitis: unclear roles of IgE and eosinophils.

Journal of internal medicine·2017
Same author

[Eosinophilic Esophagitis - Update - Pathogenesis, Diagnosis and Therapy].

Laryngo- rhino- otologie·2017
Same journal

GWAS of Second-Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Basophil Activation Test Provides Additional Diagnostic Value Beyond Ara h 2-Specific IgE Testing in Peanut Allergic Adults.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Characterisation of Allergen Profiles in Commercial Egg Products to Inform Oral Immunotherapy Strategies in Egg Allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Allergic Diseases and Risk of Incident Autoimmune Diseases: Phenotype-Specific Patterns and Multimorbidity Effects in a Nationwide Cohort.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Determinants of Total and Inhaled Allergen-Specific Immunoglobulin E in the Middle-Aged and Elderly Population.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same journal

Rhinitis-Related Healthcare Utilization in Colombian Adults, 2015-2024.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic oesophagitis: latest intelligence.

A M Schoepfer1, D Simon, A Straumann

  • 1Department of Gastroenterology and Hepatology, CHUV/University of Lausanne, Lausanne, Switzerland. alain.schoepfer@chuv.ch

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|March 25, 2011
PubMed
Summary
This summary is machine-generated.

Eosinophilic oesophagitis (EoE) is a growing cause of dysphagia, particularly in males, often linked to allergies. While topical corticosteroids and elimination diets show promise, long-term diagnostic and treatment strategies for EoE remain undefined.

More Related Videos

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Related Experiment Videos

Last Updated: Jun 3, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic oesophagitis (EoE) is a chronic esophageal inflammatory disease with rising incidence in Western countries.
  • EoE is a primary cause of dysphagia in adults, predominantly affecting males and often associated with allergies.
  • Diagnosis requires excluding other causes of esophageal eosinophilia, with diagnostic and therapeutic strategies still under development.

Purpose of the Study:

  • To review the current understanding of Eosinophilic oesophagitis (EoE).
  • To discuss diagnostic and therapeutic approaches for EoE.
  • To highlight the evolving nature of EoE management.

Main Methods:

  • Literature review of Eosinophilic oesophagitis (EoE).
  • Analysis of diagnostic criteria and exclusion of other conditions.
  • Evaluation of current therapeutic interventions including corticosteroids, diet, and dilation.

Main Results:

  • Topical corticosteroids rapidly improve clinical and histological aspects of active EoE.
  • Elimination diets are effective, especially in children, comparable to topical corticosteroids.
  • Esophageal dilation alleviates symptoms of strictures but does not address underlying inflammation.

Conclusions:

  • Eosinophilic oesophagitis (EoE) is a significant esophageal disease requiring further research into definitive diagnostic and long-term therapeutic strategies.
  • Management of EoE involves symptom control and addressing inflammation, with ongoing debate on optimal approaches.
  • The evolving understanding of EoE necessitates continued investigation into its pathogenesis and treatment.