Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

Types of Fever

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:

Methods of reducing fever

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

Patterns of Fever

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.

Decreased Body Temperature

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The rapidly evolving BCMA landscape in multiple myeloma.

Blood·2026

Same author

Long-term follow-up of the transplant-eligible cohort of the EMN12/HOVON-129 study for primary plasma cell leukemia patients.

Blood cancer journal·2026

Same author

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN).

American journal of hematology·2026

Same author

Daratumumab in Transplant-Ineligible or -Deferred Newly Diagnosed Multiple Myeloma: Minimal Residual Disease in CEPHEUS.

Blood advances·2026

Same author

Balancing Efficacy and Safety in Multiple Myeloma Patients Receiving B cell Maturation Antigen-Directed CAR T-Cell Therapy.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026

Same author

Infections in patients receiving daratumumab for newly diagnosed multiple myeloma: a pooled analysis of MAIA and ALCYONE.

Blood advances·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

[An immunocompromised man with a fever].

Sandra Nathalie Stapel¹, Sonja Zweegman

¹VU Medisch Centrum, afd. Hematologie, Amsterdam, the Netherlands. s.stapel@vumc.nl

Nederlands Tijdschrift Voor Geneeskunde

|March 25, 2011

Summary

Pyomysitis, a rare bacterial infection, can occur in patients with prolonged corticosteroid use. This case highlights Staphylococcus aureus as a cause in a patient with plasmacytoma on dexamethasone therapy.

Area of Science:

Infectious Diseases
Oncology
Rheumatology

Background:

Prolonged use of corticosteroids, such as dexamethasone, is common in managing various conditions, including recurrent plasmacytoma.
Immunosuppression secondary to corticosteroid therapy can increase the risk of opportunistic infections.

Observation:

A 42-year-old male patient with a history of recurrent plasmacytoma on long-term dexamethasone presented with fever.
The patient exhibited tender, red swelling in his right upper leg and arm, indicative of localized inflammation.

Findings:

Diagnostic evaluation revealed pyomysitis, a deep muscle infection characterized by pus formation.
Cultures identified Staphylococcus aureus as the causative pathogen responsible for the pyomysitis.

Related Experiment Videos

Last Updated: Jun 3, 2026

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

Implications:

This case underscores the importance of considering pyomysitis in immunocompromised patients presenting with localized swelling and fever.
Prompt diagnosis and appropriate antibiotic treatment targeting Staphylococcus aureus are crucial for managing pyomysitis in patients on immunosuppressive therapy.