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Saliva electrophoretic protein profiles in infants: changes with age and impact of teeth eruption and diet transition

M Morzel1, O Palicki, C Chabanet

  • 1Centre des Sciences du Goût et de l'Alimentation (UMR1324 INRA, UMR6265 CNRS, Université de Bourgogne), F-21000 Dijon, France. Martine.Morzel@dijon.inra.fr

Archives of Oral Biology
|March 25, 2011
PubMed

Insights

Salivary protein profiles in infants change significantly between 3 and 6 months. Teeth eruption and solid food introduction impact these salivary changes, revealing dynamic interactions.

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Pediatric Health

Background:

  • Infant salivary composition undergoes dynamic changes during early development.
  • Understanding these changes is crucial for assessing oral health and developmental milestones.

Purpose of the Study:

  • To characterize salivary protein profile alterations in infants aged 3 to 6 months.
  • To investigate the influence of tooth eruption and solid food introduction on infant saliva proteome.

Main Methods:

  • Longitudinal study of 73 infants at 3 and 6 months.
  • Saliva protein separation via SDS-PAGE and semi-quantification.
  • Amylase activity measurement and mass spectrometry for protein identification.

Main Results:

  • 13 out of 21 protein bands showed significant changes between 3 and 6 months.
  • Amylase variants and activity increased with age; immune system maturation suggested by other changes.
  • Tooth eruption correlated with increased albumin; solid foods linked to higher beta-2 microglobulin and S-type cystatins.

Conclusions:

  • Infant salivary proteome significantly evolves between 3 and 6 months.
  • Tooth eruption and diet composition demonstrably influence salivary protein levels.
  • These findings highlight the interplay between saliva, oral development, and infant nutrition.
Abstract

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