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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Neurohormonal activity and vascular properties late after aortic coarctation repair

Antonia C Moutafi1, Themis Alissafi, Aikaterini Chamakou

  • 1Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece.

International Journal of Cardiology
|March 25, 2011
PubMed

Insights

Adults with repaired coarctation of aorta (CoA) show persistent vascular dysfunction and inflammation. This may explain late cardiovascular complications despite successful surgical repair.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Vascular Biology

Background:

  • Coarctation of the aorta (CoA) can lead to late cardiovascular complications after repair.
  • The underlying causes of these late complications remain unclear.
  • This study investigates neurohormonal, immune, and vascular elastic properties in adults with repaired CoA.

Purpose of the Study:

  • To assess vascular elastic properties in adults with repaired coarctation of the aorta (CoA).
  • To measure plasma levels of cytokines and neurohormones in repaired CoA patients.
  • To understand the mechanisms behind late cardiovascular complications in CoA patients.

Main Methods:

  • Nineteen adult patients with repaired CoA and 29 healthy controls were studied.
  • Aortic distensibility and stiffness index were measured.
  • Peripheral vessel elasticity, forearm blood flow, and plasma cytokine/neurohormone levels were assessed.

Main Results:

  • Repaired CoA patients exhibited reduced aortic distensibility and increased stiffness.
  • Higher augmentation index and pressure, with reduced forearm blood flow, were observed in CoA patients.
  • Elevated plasma levels of sICAM-1, sVCAM-1, E-selectin, sFas-ligand, and IL-10 were found in CoA patients.

Conclusions:

  • Adults with repaired CoA show a late inflammatory response.
  • Functional vascular problems persist across all vessels, irrespective of the initial coarctation site.
  • This inflammatory state may contribute to late cardiovascular complications post-CoA repair.
Abstract

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