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Is left ventricular hypertrophy a low-level inflammatory state? A population-based cohort study

S Bo1, C Mandrile, N Milanesio

  • 1Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy. sbo@molinette.piemonte.it

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|March 25, 2011
PubMed

Insights

Left ventricular hypertrophy (LVH) is linked to systemic inflammation. This study shows baseline LVH predicts higher C-reactive protein (CRP) levels at follow-up, independent of other risk factors.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Biomarkers

Background:

  • Conflicting evidence exists on the association between sub-clinical inflammation and left ventricular hypertrophy (LVH).
  • Investigating the link between baseline LVH and high-sensitivity C-reactive protein (CRP) is crucial for understanding cardiovascular health.
  • Previous cross-sectional studies suggest a connection, but longitudinal data is needed.

Purpose of the Study:

  • To examine the association between baseline left ventricular hypertrophy (LVH) and high-sensitivity C-reactive protein (CRP) levels.
  • To determine if baseline LVH predicts future CRP levels in a population-based cohort.
  • To assess this association in both a general population and a healthier subgroup, excluding common confounding factors.

Main Methods:

  • A population-based cohort (n=1564) and a healthier subgroup (n=515) were analyzed.
  • Left ventricular hypertrophy (LVH) was assessed using ECG criteria (Cornell voltage-duration product).
  • High-sensitivity C-reactive protein (CRP) levels were measured at baseline and after a six-year follow-up, with adjustments for confounders.

Main Results:

  • 10.6% of subjects exhibited baseline left ventricular hypertrophy (LVH).
  • Individuals with LVH had higher BMI, waist circumference, blood pressure, and CRP levels at baseline and follow-up.
  • Baseline LVH independently predicted higher CRP levels at follow-up in multivariable regression models.

Conclusions:

  • Baseline left ventricular hypertrophy (LVH) is associated with systemic inflammation.
  • LVH predicts elevated C-reactive protein (CRP) levels at follow-up, independent of cardiovascular and metabolic risk factors.
  • The inflammatory pathways linked to LVH warrant further investigation.
Abstract

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