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[Safety and efficacy of continuous infusion propofol for diagnostic upper gastrointestinal endscopy in spontaneous

F J Alados-Arboledas1, P Millán-Bueno, J F Expósito-Montes

  • 1Unidad de Cuidados Intensivos Pediátricos, UGC Pediatría, Hospital Materno-Infantil de Jaén, España. fjaladosarbol@ono.com

Anales De Pediatria (Barcelona, Spain : 2003)
|March 25, 2011
PubMed

Insights

Continuous propofol infusion provides safe and effective sedation for pediatric upper gastrointestinal endoscopy. This method ensures successful procedures and amnesia in young patients undergoing diagnostic evaluations.

Area of Science:

  • Pediatric Anesthesiology
  • Gastroenterology
  • Pharmacology

Background:

  • Invasive procedures in pediatric intensive care units (PICU) necessitate specialized anesthetic approaches.
  • Deep sedation is frequently required for pediatric patients undergoing procedures like upper gastrointestinal endoscopy (UGE).

Purpose of the Study:

  • To evaluate the safety and efficacy of continuous propofol infusion for sedation during diagnostic UGE in spontaneously breathing pediatric patients.
  • To assess the feasibility of achieving a modified Ramsay scale score of 5-6 and procedural amnesia.

Main Methods:

  • A prospective observational study was conducted in a secondary hospital's PICU.
  • The study involved 31 pediatric patients undergoing diagnostic UGE.
  • A sedation-analgesia protocol included fentanyl and a continuous propofol infusion (3-4 mg/kg/h, max 6 mg/kg/h).

Main Results:

  • The procedure was successfully completed in 100% of patients.
  • Amnesia was achieved in all patients over 4 years old (21/21).
  • The only adverse effect noted was vomiting in one patient.

Conclusions:

  • Continuous propofol infusion is a safe and effective method for sedating pediatric patients during diagnostic UGE.
  • This sedation strategy supports successful endoscopic procedures in spontaneously breathing children.
  • The protocol achieved desired sedation levels and amnesia, with minimal adverse events.
Abstract

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