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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
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Learning from the 2009 H1N1 pandemic: prospects for more broadly effective influenza vaccines
Ethan C Settembre1, Philip R Dormitzer, Rino Rappuoli
1Novartis Vaccines and Diagnostics, Cambridge, MA, USA.
Abstract:
Calls to develop a universal influenza vaccine have increased in the wake of the 2009 H1N1 influenza pandemic. This demand comes at a time when analyses of the human antibody repertoire, informed by structures of complexes between broadly neutralizing antibodies and influenza hemagglutinin, have revealed the target of a class of broadly neutralizing antibodies. Recent studies suggest a path forward to more broadly protective influenza vaccines.
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