Breastfeeding and infant size: evidence of reverse causality
Michael S Kramer1, Erica E M Moodie, Mourad Dahhou
1Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada. michael.kramer@mcgill.ca
Insights
Smaller infant size, particularly weight for age, increases the risk of weaning or stopping exclusive breastfeeding. This suggests infant growth influences feeding decisions, complicating breastfeeding research.
Area of Science:
- Pediatrics
- Human Nutrition
- Public Health
Background:
- Prolonged and exclusive breastfeeding is associated with slower infant growth in the first year.
- Infant feeding and growth are dynamic processes influenced by bidirectional interactions.
- Previous research may oversimplify the causal link between breastfeeding and growth due to these complex dynamics.
Purpose of the Study:
- To investigate the influence of infant size on subsequent infant feeding decisions.
- To assess whether smaller infant size predicts weaning or discontinuation of exclusive breastfeeding.
- To explore the dynamic relationship between infant growth and feeding patterns.
Main Methods:
- Observational analysis of 17,046 Belarusian infants from a cluster-randomized trial.
- Analysis restricted to breastfed infants at the start of follow-up intervals.
- Examined associations between infant size (weight/length) and subsequent weaning or cessation of exclusive breastfeeding.
Main Results:
- Smaller infant size, especially weight-for-age, was significantly associated with increased risk of weaning (aOR=1.2-1.6).
- Smaller size also significantly increased the risk of discontinuing exclusive breastfeeding (aOR=1.2-1.6).
- These associations were most pronounced between 2 and 6 months of age.
Conclusions:
- Infant size, particularly smaller size, appears to influence decisions regarding breastfeeding duration and exclusivity.
- Dynamic processes, including infant size influencing feeding, complicate causal inferences about breastfeeding's effect on growth.
- Further research is needed to disentangle the complex interplay between infant growth and feeding behaviors.
Abstract:
Infants who receive prolonged and exclusive breastfeeding grow more slowly during the first year of life than those who do not. However, infant feeding and growth are dynamic processes in which feeding may affect growth, and prior growth and size may also influence subsequent feeding decisions. The authors carried out an observational analysis of 17,046 Belarusian infants who were recruited between June 1996 and December 1997 and who participated in a cluster-randomized trial of a breastfeeding promotion intervention. To assess the effects of infant size on subsequent feeding, the authors restricted the analysis to infants breastfed (or exclusively breastfed) at the beginning of each follow-up interval and examined associations between weight or length at the beginning of the interval and weaning or discontinuation of exclusive breastfeeding by the end of the interval. Smaller size (especially weight for age) was strongly and statistically significantly associated with increased risks of subsequent weaning and of discontinuing exclusive breastfeeding (adjusted odds ratios = 1.2-1.6), especially between 2 and 6 months, even after adjusment for potential confounding factors and clustered measurement. The authors speculate that similar dynamic processes involving infant crying, other signs of hunger, and supplementation/weaning undermine causal inferences about the "effect" of prolonged and exclusive breastfeeding on slower infant growth.
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