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Inflammation

Inflammation

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 3, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.

Rossana C N Melo¹, Heloisa D'Avila, Hsiao-Ching Wan

¹Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, MG, Brazil. rossana.melo@ufjf.edu.br

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

|March 25, 2011

Summary

This summary is machine-generated.

Lipid bodies (LBs) are active organelles in immune cells, crucial for inflammation and disease. Understanding their structure and imaging is key for developing new anti-inflammatory therapies.

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Area of Science:

Cell Biology
Immunology
Molecular Medicine

Background:

Lipid bodies (LBs), also known as lipid droplets, are increasingly recognized as active organelles.
They are formed in immune cells like macrophages and neutrophils during inflammation.
LBs are involved in synthesizing and storing inflammatory mediators.

Purpose of the Study:

To review the structural and functional aspects of lipid bodies.
To discuss current imaging techniques for visualizing LBs in inflammatory cells.
To highlight the role of LBs in inflammatory diseases and as therapeutic targets.

Main Methods:

Literature review focusing on lipid body biology and imaging.
Analysis of the dynamic morphological changes of LBs in leukocytes.
Examination of LBs in the context of infectious diseases and inflammatory conditions.

Main Results:

Lipid bodies are inducible organelles dynamically formed in leukocytes upon activation.
Their morphology and presence are key markers of leukocyte activation.
LBs play critical roles in regulating various inflammatory diseases.

Conclusions:

Lipid bodies are essential regulators in inflammatory processes and diseases.
They serve as important biomarkers for leukocyte activation.
Targeting lipid bodies offers a promising strategy for novel anti-inflammatory therapies.