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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Related Experiment Video

Updated: Jun 3, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

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Published on: January 21, 2020

The economics associated with persistent pain.

Ceri J Phillips1, Christie Harper

  • 1Swansea Centre for Health Economics, College of Human and Health Sciences, Swansea University, Swansea, Wales, UK. C.J.Phillips@swansea.ac.uk

Current Opinion in Supportive and Palliative Care
|March 25, 2011
PubMed
Summary

Persistent pain significantly impacts individuals and society, leading to substantial economic burdens through healthcare costs, reduced productivity, and labor market withdrawal. Effective pain management is crucial for economic well-being.

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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Area of Science:

  • Health Economics
  • Pain Management
  • Public Health Policy

Background:

  • Persistent pain affects individuals, families, and communities.
  • The economic burden of pain is substantial and widespread.
  • Pain's impact exceeds many other health conditions.

Purpose of the Study:

  • To assess the economic impact of inadequate, inappropriate, and ineffective persistent pain treatments.
  • To evaluate the economic burden from individual, familial, community, healthcare, and societal perspectives.

Main Methods:

  • This is a review article.
  • The study synthesizes existing research on the economic consequences of persistent pain.

Main Results:

  • Persistent pain imposes a significant economic burden on individuals, families, employers, and economies.
  • Key economic impacts include absenteeism, reduced productivity, labor market exit, and increased healthcare costs.
  • The economic impact of persistent pain is demonstrably greater than most other health conditions.

Conclusions:

  • The societal and individual costs of persistent pain necessitate a strategic approach to service provision and resource allocation.
  • Policymakers and healthcare decision-makers must adopt a broad perspective to address the economic burden of pain.
  • Investing in effective pain management is essential for mitigating economic losses and improving societal well-being.