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Mometasone-based triple combination therapy in melasma: is it really safe?
1Cutis Skin and Laser Clinic, Government Medical College, Srinagar, Kashmir, India.
Indian Journal of Dermatology
|March 25, 2011
Summary
This study found that a popular melasma treatment, the mometasone-based triple combination, frequently causes steroid side effects like telangiectasia and skin atrophy. Physicians should consider these risks when prescribing this melasma therapy.
Area of Science:
- Dermatology
- Cosmetic Science
Background:
- Kligman's triple combination formula is a widely used melasma treatment.
- A recent modification involves 2% hydroquinone, 0.025% tretinoin, and 1% mometasone.
- Increased use of this triple combination has highlighted its side effect profile.
Purpose of the Study:
- To evaluate the safety of mometasone-based triple combination treatment for melasma.
- To assess the incidence of adverse effects associated with this melasma therapy.
Main Methods:
- Retrospective study of 60 melasma patients using the triple combination for at least 3 weeks.
- Patients completed questionnaires on treatment effects and sun sensitivity.
- Dermatologist assessed for adverse effects like telangiectasia, hypertrichosis, acne, and skin atrophy.
Main Results:
- Over half of patients used the treatment longer than recommended.
- 36.7% reported their melasma worsened after treatment.
- 43.3% experienced steroid side effects, including telangiectasia (most common), skin atrophy, hypertrichosis, and acneiform eruptions.
Conclusions:
- Mometasone-based triple combination therapy carries a significant risk of steroid-induced adverse effects.
- Healthcare providers must consider these potential side effects when prescribing this melasma treatment.
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