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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Warfarin-induced eosinophilic pleural effusion.

Yong-Min Jo¹, Tae-Ho Park, Il-Hwan Jeong

¹Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

Korean Circulation Journal

|March 25, 2011

Summary

Warfarin, a common anticoagulant, can cause eosinophilic pleural effusion, a rare lung condition. This case highlights a potential adverse effect of warfarin therapy in pulmonary thromboembolism patients.

Keywords:

Pleural effusion Warfarin

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Area of Science:

Pulmonology
Pharmacology
Internal Medicine

Background:

Pulmonary thromboembolism is a serious condition often treated with anticoagulants like warfarin.
Pleural effusion is a known, albeit uncommon, complication of certain medications.

Purpose of the Study:

To report the first case of warfarin-induced pleural effusion in Korea.
To raise awareness of this rare adverse drug reaction.

Main Methods:

Case report of a 29-year-old male patient.
Clinical evaluation including diagnostic imaging and laboratory tests.
Exclusion of other potential causes for pleural effusion.

Main Results:

The patient developed dyspnea and eosinophilic pleural effusion.
Warfarin was identified as the likely etiology after excluding other causes.
This represents the first documented case in Korea.

Conclusions:

Warfarin should be considered as a potential cause of eosinophilic pleural effusion.
Physicians should maintain a high index of suspicion for drug-induced pleural effusion in patients on warfarin.
Further investigation into the mechanism of warfarin-induced pleural effusion is warranted.