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Updated: Jun 3, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Pictorial essay: The many faces of craniosynostosis

Paritosh C Khanna1, Mahesh M Thapa, Ramesh S Iyer

  • 1Department of Radiology, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, Washington, USA.

The Indian Journal of Radiology & Imaging
|March 25, 2011
PubMed

Insights

Craniosynostosis, a common pediatric condition, involves premature skull fusion. This review details its mechanisms, types, associated syndromes, and imaging

Area of Science:

  • Pediatric Radiology
  • Craniofacial Surgery
  • Medical Imaging

Background:

  • Craniosynostosis is the premature fusion of one or more cranial sutures in infants.
  • It can occur as an isolated defect or as part of a broader craniofacial syndrome.
  • Understanding the pathophysiology is crucial for diagnosis and management.

Purpose of the Study:

  • To provide a pictorial review of craniosynostosis.
  • To illustrate the mechanisms, pathophysiology, and imaging findings.
  • To cover various types of craniosynostoses and associated syndromes.

Main Methods:

  • This is a pictorial review, relying on illustrative radiological images.
  • The review synthesizes information on the underlying mechanisms and pathophysiology.
  • It includes common craniofacial syndromes associated with craniosynostosis.

Main Results:

  • The review visually demonstrates different types of craniosynostosis.
  • It highlights the role of various imaging modalities in diagnosis.
  • Pathophysiological mechanisms are explained through imaging examples.

Conclusions:

  • Imaging plays a critical role in diagnosing and managing craniosynostosis.
  • A comprehensive understanding of craniosynostosis and its syndromes aids in patient care.
  • This review serves as a visual guide for clinicians.

Keywords:
3-dimensional computed tomographyCraniosynostosiscraniofacial syndromesmagnetic resonance imaging

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