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Updated: Jun 3, 2026
08:54
In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Ozone as u-shaped dose responses molecules (hormetins).
G Martínez-Sánchez1, G Pérez-Davison, L Re
1Medinat srl Clinic, Camerano, Italy.
Summary
Ozone therapy, a hormetic treatment, can induce antioxidant responses to combat oxidative stress. This approach may offer new avenues for redox-related disease research and healthy aging.
Area of Science:
- Redox biology and oxidative stress.
- Cellular adaptive stress responses.
- Hormesis and its biological implications.
Background:
- The redox environment comprises pro-oxidant and antioxidant factors.
- Cellular stress responses can lead to health benefits or damage.
- Hormesis involves adaptive responses to mild stressors, enhancing defense capacity.
Purpose of the Study:
- To explore the role of ozone therapy within the framework of hormesis.
- To investigate ozone's potential as a hormetin in redox-related interventions.
- To highlight the application of hormesis principles in healthy aging and disease research.
Main Methods:
- Reviewing the effects of ozone on reactive oxygen species and lipid peroxides.
- Examining the induction of antioxidant enzymes during ozone therapy.
- Analyzing the concept of hormetic amplification in biological systems.
Main Results:
- Ozone, at appropriate doses, acts as a messenger by promoting reactive oxygen species and lipid peroxides.
- Ozone therapy has been observed to increase antioxidant enzyme levels.
- Ozone can be considered a hormetin, inducing beneficial adaptive responses.
Conclusions:
- Ozone therapy aligns with hormesis principles by inducing antioxidant responses.
- Hormesis, through ozone or other hormetins, offers potential for healthy aging.
- Established hormesis science can guide new interventions for redox-related diseases, with ozone therapy as a promising candidate.
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