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[Correlation between single nucleotide polymorphism and periodontitis susceptibility in Shanghai Chinese patients]
Dong Chen1, Kun Feng, Li-Ming Wang
1Department of Oral Medicine,Shanghai Stomatological Disease Center. Shanghai 200031,China. chendong19690124@sohu.com
Purpose:
To investigate the correlation between 12 single nucleotide polymorphisms (SNPs) from 7 genes and periodontitis of susceptibility in Shanghai Chinese patients.
Methods:
Genotypes of randomly grouped 50 health control subjects and 48 patients with chronic periodontitis were genotyped by MALDI-TOF MS detection system. A questionnaire, medical history, family history, signs, laboratory tests, treatment, follow-up information were collected. Statistical analysis of Chi-square test was performed using SPSS13.0 software package.
Results:
In the screening of the 12 target SNPs,the GG genotype of rs2891168 correlated significantly with periodontitis, OR=3.071(95%CI:1.018-9.260,P=0.046).
Conclusion:
The GG genotype of rs2891168 may correlate significantly with periodontitis of Shanghai Chinese patients and further studies are needed to verify this finding. Supported by Natural Science Foundation of Shanghai Municipality (Grant No.10ZR1425900) and Research Fund of Bureau of Health of Shanghai Municipality (Grant No.2009202).
