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Updated: Jun 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
The potential role of cardiac resynchronization therapy in acute heart failure syndromes
Norman C Wang1, Sanjoy Bhattacharya, Mihai Gheorghiade
1Cardiovascular Institute, University of Pittsburgh Medical Center, 200 Lothrop Street B-535, Pittsburgh, PA 15213, USA. wangnc@upmc.edu
Abstract:
Cardiac resynchronization therapy (CRT) has been demonstrated to improve mortality and morbidity in patients with chronic, stable heart failure who have reduced left ventricular ejection fraction and prolonged QRS duration. Patients with acute heart failure syndromes (AHFS) have been excluded from major CRT trials. The potential benefits and risks of implementation of these devices in the AHFS setting are largely unknown. In this review, we discuss the role that early implementation of CRT may have in improving postdischarge outcomes. In addition, we also discuss the potential adverse consequences of inserting these devices in patients who are in the tenuous clinical state of AHFS.
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