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Updated: Jun 3, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Positive patch test for mercury possibly from exposure to amalgam.

Tomio Mori¹, Kazuhiro Sato, Yukinori Kusaka

¹Fukui Prefectural Institute of Public Health and Environmental Science, 39-4, Harame-cho, 910-8551, Fukui-city, Fukui, Japan, moritomio@fklab.fukui.fukui.jp.

Environmental Health and Preventive Medicine

|March 25, 2011

Summary

Mercury allergy is linked to higher mercury levels in urine, especially in the morning. Dental amalgam fillings and exposure to mercury from fish or mercurochrome increase these levels.

Keywords:

allergy amalgam mercury patch test

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Last Updated: Jun 3, 2026

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Area of Science:

Environmental Health
Toxicology
Dermatology

Background:

Mercury allergy presents a significant health concern.
Understanding mercury exposure sources is crucial for managing allergic reactions.

Purpose of the Study:

To investigate the correlation between positive mercury patch tests and various mercury exposure indicators.
To identify environmental and biological factors associated with mercury exposure in healthy students.

Main Methods:

580 students underwent mercury patch testing (Hg-PT).
Mercury levels in urine (Hg-u) and hair (Hg-h) were measured in positive (Hg-PT(+)) and negative (Hg-PT(-)) groups.
Fish intake, mercurochrome use, and amalgam fillings (NA) were assessed via questionnaires and dental examination.

Main Results:

Male students with positive Hg-PT showed elevated Hg-u and Hg-h compared to the negative group.
Increased fish intake, mercurochrome use, and NA were independently associated with higher morning Hg-u in both genders.
Number of amalgam fillings (NA) significantly impacted morning Hg-u.

Conclusions:

Higher numbers of dental amalgam fillings correlate with increased morning urinary mercury levels.
Exposure to dental amalgam may contribute to elevated mercury levels.
Positive mercury patch tests may indicate higher mercury exposure, potentially linked to amalgam fillings.