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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Perfusion imaging with a freely diffusible hyperpolarized contrast agent.

Aaron K Grant1, Elena Vinogradov, Xiaoen Wang

  • 1Department of Radiology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. akgrant@bidmc.harvard.edu

Magnetic Resonance in Medicine
|March 25, 2011
PubMed
Summary
This summary is machine-generated.

Hyperpolarized 2-methyl-2-propanol shows promise as a freely diffusible contrast agent for magnetic resonance perfusion imaging. Its ability to be imaged with high temporal resolution and long residence time in tissue makes it suitable for brain and body imaging.

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Area of Science:

  • Magnetic Resonance Imaging
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Freely diffusible contrast agents are valuable for perfusion imaging.
  • Hyperpolarized agents offer enhanced signal for MRI.

Purpose of the Study:

  • To evaluate hyperpolarized (13)C labeled 2-methyl-2-propanol as a freely diffusible contrast agent for perfusion imaging.
  • To assess its suitability for dynamic imaging in the rat brain.

Main Methods:

  • Dynamic (13)C imaging using a balanced steady-state free precession sequence.
  • Relaxation measurements (T1 and T2) in blood and brain tissue.
  • Analysis of temporal image intensity dynamics.

Main Results:

  • Hyperpolarized 2-methyl-2-propanol was imaged with 2-4s temporal resolution and adequate signal-to-noise ratio.
  • The agent demonstrated T1 and T2 relaxation times suitable for perfusion imaging.
  • Evidence of free diffusion and long residence time in rat brain tissue was observed.

Conclusions:

  • Hyperpolarized 2-methyl-2-propanol is a promising agent for robust and quantitative perfusion imaging.
  • Its characteristics support its use in both brain and body imaging applications.
  • The agent's free diffusion and imaging properties enable continuous monitoring for extended periods.