Related Experiment Video
Updated: Jun 3, 2026

Intermittent Binge-Intake Model in Mice
Published on: January 10, 2025
A dangerous combination of binge and purge
Alison Culkin1, Simon M Gabe, Simon T C Peake
1Department of Nutrition and Dietetics, St Mark's Hospital, Harrow, England. Alison.culkin@nwlh.nhs.uk
Abstract:
We present a 36-year-old female diagnosed with Crohn's disease at the age of 11 years. In 2001, she underwent a total colectomy and further small bowel resection as a result of active Crohn's. Her residual anatomy consisted of 150 cm of small bowel to an end jejunostomy. Subsequently, she developed short bowel syndrome with recurrent episodes of hypomagnesaemia, hypocalcaemia, and hypokalaemia. Dietetic assessment revealed her to be severely underweight at 37 kg with a bodymass index (BMI) of 14.4 kg/m(2) . During her admission, our patient underwent psychiatric assessment and was established on home parenteral nutrition (HPN). At the time of discharge, 1 month later, her weight had increased to 44 kg (BMI = 17.7 kg/m(2) ). Over the following 12-month period, she lost weight (BMI, 15.4 mg/m(2) ; weight, 39.5 kg) and she described a high stoma output (up to 17 L) and dehydration. Assessment of her oral intake found she was consuming an estimated 14,000 kcal and 600 g protein per day. At this time, the possibility of a new form of eating disorder was discussed with the patient and she agreed that her behavior i.e., using her stoma as a purging device, fulfilled the criteria for a diagnosis of bulimia nervosa and she was referred to a specialist eating disorder unit.
Related Concept Videos
Bulimia Nervosa
Binge Eating Disorders
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Borderline Personality Disorder
Genetic and Environmental Contributions
Borderline Personality...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Abuse and Addiction: Pharmacological Phenomena

