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Updated: Jun 3, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Precise synthesis of molecularly defined oligomers and polymers by orthogonal iterative divergent/convergent
Sandra Binauld1, Denis Damiron, Luke A Connal
1Center for Advanced Macromolecular Design, School of Chemical Engineering, The University of New South Wales, UNSW Sydney, NSW 2052, Australia.
Abstract:
The synthesis of perfectly defined (macro)molecules has been a constant challenge for polymer and organic chemists. This paper highlights the main applications of the iterative divergent/convergent approach for the synthesis of discrete mass oligomers and polymers. We will discuss the orthogonal deprotection and coupling strategies involved in this powerful strategy where chain length doubles at each iteration and which has been applied to the synthesis of conjugated rigid rods as well as amorphous and crystalline oligomers and polymers. The synthesis of perfectly defined oligomers in respect to emerging highly efficient and orthogonal chemistries will also be highlighted.
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