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Updated: Jun 3, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Mono-, di-, or triazidated cyclodextrin-based polyrotaxanes for facile and efficient functionalization via click
1School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923-1292, Japan.
Abstract:
As a feasible way for controlling the density of ligands in polyrotaxanes, azidated polyrotaxanes comprising PEG (MW= 3,000 and 20,000 g · mol(-1)) and mono-, di-, or triazidated α-cyclodextrins are prepared in a water/DMSO solution in a one-pot synthesis. The azidated polyrotaxanes are then allowed to conjugate with propargyl-modified mannose as a ligand via click chemistry. As proven by FTIR spectroscopy and (1)H NMR-spectroscopy, mannose molecules are efficiently introduced into all of the azide moieties of the polyrotaxanes. The results verify the achievement of ligand-density-controlled polyrotaxanes. The functionalized polyrotaxanes can be utilized for a variety of biological applications.
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